I tried updating IE to 7 it made no change with the error/lock up.
Sadly, OWA does not function properly in Firefox, so I'm stuck using IE6.
In the new deployment I troubleshooted 3 issues in a day so share the experience here which might help someone.
OWA does not work after Load balancing Exchange 2016 while using Kemp LoadBalancers | 360 ICT Technical Blog 15:39 360 ICT Technical Blog 360 ICT Technical Blog ← Exchange 2013 Post SP1 with Kemp LoadBalancers exRCA ActiveSync error: operation timed out ping to MAPI Mail Store Endpoint failed in exRCA while Load balancing.
The first two are not needed if you do not sync your iPhone, iPad or iPod with Outlook via iTunes. For instance, iTunes adds the following 3 add-ins to Outlook: iTunes Outlook AddIn.
Other applications may also add add-ins to Outlook which you might not have expected at first.
You'll then have to uncheck all selectable proxy protocols and check to see if the ERR_CONNECTION_TIMED_OUT message has been resolved. If you're a Mac user, you should immediately find yourself in the relevant menu.
Windows users will want to click on LAN Settings and uncheck the Use proxy server for LAN option.